Alternative polyadenylation: methods, mechanism, function, and role in cancer
نویسندگان
چکیده
منابع مشابه
Alternative Polyadenylation: Methods, Findings, and Impacts
Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3' ends originate from distinct polyadenylation sites of a single gene, is emerging as a mechanism widely used to regulate gene expression. In the present review, we first summarized various methods prevalently adopted in APA study, mainly focused on the next-generation sequencing (NGS)-based techniques specially ...
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Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer puzzle are still missing. In an effort to have a more comprehensiv...
متن کاملRole of alternative polyadenylation in epigenetic silencing and antisilencing.
Epigenetic marks such as DNA methylation and histone modifications are widely involved in regulating different aspects of developmental and environmental responses (1). Meanwhile, DNA methylation and histone modification are also used constitutively to silence transposable elements and repeat elements (TREs) (2). Such TRE-mediated silencing should necessarily be limited to the intended targets ...
متن کاملAlternative cleavage and polyadenylation during colorectal cancer development.
PURPOSE Alternative cleavage and polyadenylation (APA) of mRNAs is a phenomenon that alters 3'-untranslated region length leading to altered posttranscriptional regulation of gene expression. Changing APA patterns have been shown to result in misregulation of genes involved in carcinogenesis; therefore, we hypothesized that altered APA contributes to progression of colorectal cancer, and that m...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2021
ISSN: 1756-9966
DOI: 10.1186/s13046-021-01852-7